Journal of Bone and Joint Surgery – British Volume, Vol 91-B, Issue 7,
H. Koivu, MD, Orthopaedic Surgeon1; I. Kohonen, MD, Radiologist2; E. Sipola, MD, Orthopaedic Surgeon3; K. Alanen, MD, PhD, Pathologist4; T. Vahlberg, MSc, Biostatistician5; and H. Tiusanen, MD, PhD, Orthopaedic Surgeon3 Between 2002 and 2008, 130 consecutive ankles were replaced with an hydroxyapatite (HA) and titanium-HA-coated Ankle Evolutive System total ankle prosthesis. Plain radiographs were analysed by two independent observers. Osteolytic lesions were classified by their size and location, with cavities > 10 mm in diameter considered to be marked. CT scanning was undertaken in all patients with marked osteolysis seen on the plain radiographs. Osteolytic lesions were seen on the plain films in 48 (37%) and marked lesions in 27 (21%) ankles. The risk for osteolysis was found to be 3.1 (95% confidence interval 1.6 to 5.9) times higher with implants with Ti-HA porous coating. Care should be taken with ankle arthroplasty until more is known about the reasons for these severe osteolyses.