Relación entre la graduación radiográfica de la osteoartritis y los marcadores bioquímicos para la artritis en la osteoartritis de rodilla
Masaaki Takahashi; Kenichi Naito; Masashi Abe; Tomokazu Sawada; Akira Nagano
Abstract The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 4985 years with knee OA were studied. Anteriorposterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the KellgrenLawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups: 37 patients exhibiting generalized osteoarthritis (GOA) and 34 non-GOA patients, according to the grading of their hand radiograph. C-reactive protein (CRP), urinary pyridinoline, YKL-40, plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of arthritis. The radiographic grading with the KellgrenLawrence scale revealed a significant relationship to the joint space width (P = 0.003): the joint space width decreased with increasing KellgrenLawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation (P = 0.039). Pyridinoline (P = 0.034) and TIMP-1 (P = 0.017) also exhibited a significant relationship to the KellgrenLawrence grade. In GOA evaluations, the joint space width did not differ between GOA and non-GOA patients. CRP, pyridinoline, YKL-40 and MMP-3 levels were significantly greater in GOA patients than in non-GOA patients. CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type of radiographic grading examined in the present study.