Spinal Muscular Atrophy: Manifestations and Management
J Am Acad Orthop Surg June 2012 vol. 20 no. 6 Addisu Mesfin Abstract Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by a homozygous deletion in the SMN1 gene and is manifested by loss of the anterior horn cells of the spinal cord. Classifications of the disorder are based on age of […]
The Orthopaedic Implications of Diphosphonate Therapy
J Am Acad Orthop Surg, Vol 18, No 6, June 2010 Michael J. Weaver, MD, Micah A. Miller, BS and Mark S. Vrahas, MD Diphosphonates are among the many commonly prescribed drugs for osteoporosis management. These synthetic analogues of physiologically occurring inorganic pyrophosphate bind to the hydroxyapatite crystals of bone. Diphosphonates act by decreasing the […]
Effect of Alendronate on Pseudomembrane Cytokine Expression in Patients with Aseptic Osteolysis
Holt G, Reilly J, Meek RM; Journal of Arthroplasty (Dec 2009) AIM: To determine whether alendronate alters the pseudomembrane inflammatory cytokine profile in patients with established aseptic osteolysis. METHODS: A prospective, double-blind, randomized, controlled trial was conducted. Ten individuals listed for revision surgery for aseptic failure of a primary cemented arthroplasty were randomly assigned placebo/alendronate […]
Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women.
Archer DF, Pinkerton JV, Utian WH, Menegoci JC, de Villiers TJ, Yuen CK, Levine AB, Chines AA, Constantine GD. Menopause. 2009 Nov-Dec;16(6):1079-82. OBJECTIVE: The aim of this study was to evaluate the endometrial, ovarian, and breast safety of bazedoxifene used as a treatment for postmenopausal osteoporosis. METHODS: Healthy women (aged 55-85 y) with osteoporosis were […]
Recognition and management of vitamin D deficiency.
Am Fam Physician. 2009 Oct 15;80(8):841-6. Bordelon P, Ghetu MV, Langan RC. Vitamin D deficiency affects persons of all ages. Common manifestations of vitamin D deficiency are symmetric low back pain, proximal muscle weakness, muscle aches, and throbbing bone pain elicited with pressure over the sternum or tibia. A 25-hydroxyvitamin D level should be obtained […]
Diagnosis and treatment of osteoporosis
American Family Physician 79 (3), 193-200 (Feb 2009) Sweet MG, Sweet JM, Jeremiah MP, Galazka SS; Osteoporosis affects approximately 8 million women and 2 million men in the United States. The associated fractures are a common and preventable cause of morbidity and mortality in up to 50 percent of older women. The U.S. Preventive Services […]
Giant osteoclast formation and long-term oral bisphosphonate therapy
N Engl J Med. 2009 Jan 1;360(1):53-62. Weinstein RS, Roberson PK, Manolagas SC BACKGROUND: Bisphosphonates decrease bone resorption and are commonly used to treat or prevent osteoporosis. However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients benefiting from therapy, little change, if any, has been observed in the number of […]
Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw
J Am Dent Assoc, 2009. Vol 140, No 1, 61-66. Parish P. Sedghizadeh, DDS, MS, Kyle Stanley, BS, Matthew Caligiuri, BA, Shawn Hofkes, BS, Brad Lowry, BS and Charles F. Shuler, DMD, PhD Background. Initial reports of osteonecrosis of the jaw (ONJ) secondary to bisphosphonate (BP) therapy indicated that patients receiving BPs orally were at […]
Prevalence of and Traits Associated With Low BMD Among Female Adolescent Runners
Med Sci Sports Exerc 40(12) 2008 Michelle T. Barrack; Mitchell J. Rauh; Jeanne F. Nichols Abstract Purpose: Identify the prevalence of and traits that may increase the risk of low bone mineral density (BMD) among 93 female adolescent competitive endurance runners. Methods: Participants were 93 high school runners, ages 13-18 yr, from southern California. Eating […]
Osteoporosis and osteoporotic fracture occurrence and prevention in the elderly: a geriatric perspective
Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):765-85. Boonen S, Dejaeger E, Vanderschueren D, Venken K, Bogaerts A, Verschueren S, Milisen K. Age is a major determinant of osteoporosis, but the elderly are rarely assessed and often remain untreated for this condition. Falls, co-morbidities and co-medications compound the risk of fracture in senile osteoporosis. The […]
