Columna vertebral

The Global Spine Care Initiative: care pathway for people with spine-related concerns

European Spine Journal

Volume 27, Supplement 6pp 901–914

The Global Spine Care Initiative: care pathway for people with spine-related concerns

Haldeman, S., Johnson, C.D., Chou, R. et al. Eur Spine J (2018) 27(Suppl 6): 901.



The purpose of this report is to describe the development of an evidence-based care pathway that can be implemented globally.


The Global Spine Care Initiative (GSCI) care pathway development team extracted interventions recommended for the management of spinal disorders from six GSCI articles that synthesized the available evidence from guidelines and relevant literature. Sixty-eight international and interprofessional clinicians and scientists with expertise in spine-related conditions were invited to participate. An iterative consensus process was used.


After three rounds of review, 46 experts from 16 countries reached consensus for the care pathway that includes five decision steps: awareness, initial triage, provider assessment, interventions (e.g., non-invasive treatment; invasive treatment; psychological and social intervention; prevention and public health; specialty care and interprofessional management), and outcomes. The care pathway can be used to guide the management of patients with any spine-related concern (e.g., back and neck pain, deformity, spinal injury, neurological conditions, pathology, spinal diseases). The pathway is simple and can be incorporated into educational tools, decision-making trees, and electronic medical records.


A care pathway for the management of individuals presenting with spine-related concerns includes evidence-based recommendations to guide health care providers in the management of common spinal disorders. The proposed pathway is person-centered and evidence-based. The acceptability and utility of this care pathway will need to be evaluated in various communities, especially in low- and middle-income countries, with different cultural background and resources.

Graphical abstract

These slides can be retrieved under Electronic Supplementary Material.


Delivery of health care Triage Evidence-based practice Quality of health care 


In the last two decades, there has been a significant increase in the burden and costs of spinal disorders throughout the world. This impact has been seen not only in high-income countries but also in low- and middle-income countries [12]. Non-communicable diseases such as spinal disorders are contributing a higher proportion of the total burden of disease than previously considered. At the same time in low- and middle-income countries, minimal health care resources are being expended internally and through international health care priorities to reduce the disability associated with spinal disorders. In high-income countries, such as the USA, there has been a marked and progressive increase in the cost of health care for people with spinal disorders with a concomitant increase in spine-related disability [34].

Disability and costs attributed to spinal pain are projected to increase, which is a concern particularly for low- and middle-income countries where the infrastructure may be fragile and not equipped to cope with a growing burden [5]. There is an increasing call to action by leaders in the spine care community who stress it is essential to prevent the use of practices that are ineffective, harmful or wasteful of limited resources [6]. The concern is that fragmented and outdated models of care fail to address widespread misconceptions in the population and among health professionals about the causes, prognosis, and effectiveness of different treatments for spinal pain [6].

Controlled clinical trials have been the primary tool to assess the benefits and harms of common interventions for the management of spinal pain with the assumption that this will improve outcomes and reduce the costs and disability associated with spinal disorders. These trials have been performed in high-income countries, so little is known about low- and middle-income countries. At the same time, task forces, government, and professional committees have reviewed and synthesized the results of this research to develop clinical practice guidelines. These guidelines have focused primarily on non-specific or axial low back and neck pain although guidelines have also been developed to address specific pathological spinal disorders, such as spinal stenosis, spondyloarthropathies, scoliosis, and radiculopathy. Implementation of these guidelines, however, has proved difficult [789]. The difficulty in implementation and failure of clinicians to follow guidelines in high-income countries has been attributed to complex issues including provider and patient behavior, health literacy, legal, and systems/reimbursement issues.

There are challenges to implementing evidence-based guidelines in any health care community. In many communities, health care providers are scarce [10] or the primary care clinician or team of providers may not have the experience, relevant professional training, or resources to implement evidence-based management for the wide spectrum of spinal disorders. For low- and middle-income countries, resources are scarce [1112], thus providers may be less likely to have the skills and resources to manage spine-related concerns. Patients in these settings present with a full spectrum of spine-related disorders such as low back, middle back and neck pain, which might be acute, chronic, and/or episodic or recurrent and associated with varying degrees of impairment of function or activities of daily living. The incidence of chronic diseases in low- and middle-income countries is higher than in high-income countries [1314]. As well, primary health care could perform better within the care delivery system in underserved areas [1215]. There may be no imaging or laboratory testing facilities readily available at the primary care level and advanced imaging and testing may not be available even at secondary care centers or district hospitals [16]. Some communities have no or few clinicians that commonly manage spinal disorders, such as chiropractors, psychologists or physical therapists. There may be limited access to medical specialists in the fields of psychiatry, rheumatology, neurology, psychiatry, or spine surgery at secondary care and even at the tertiary centers where patients with the most serious spinal pathology are likely to be referred. There may not be resources available to manage the complications of the interventions recommended in guidelines such as gastric bleeding from non-steroidal anti-inflammatory drugs (NSAIDs), constipation, and addiction from opioids, follow-up care and rehabilitation following surgery and psychiatric and psychological care that often is associated with chronic pain. Thus, there is a need to develop a care pathway that could address these concerns and that could be adapted to the community and available resources.

Care pathways are “a complex intervention for mutual (between patient and clinician) decision-making and organization of care processes for a well-defined group of patients during a well-defined period” [17]. Care pathways have been proposed as a means of implementing guidelines into specific clinical settings. A care pathway provides a mechanism whereby multiple guidelines can be integrated and modified to adapt to the available professional and physical resources. They are a means of coordinating health care and to provide a mechanism for integrating evidence-based health care with real-world clinical practice. Chawla et al. [18] describe this process as having the “goal of using high-quality evidence for pathway development and affording physician flexibility in implementation”. Care pathways “are used to reduce variation (in care), improve the quality of care, and maximize the outcomes for specific groups of patients” [19]. Cavlan et al. [20] describe care pathways as being organized by the stages of care and including the full range of interventions that may be offered at each stage. They note that pathways should include all treatments, ranging from primary prevention to rehabilitative services, that may be offered to patients and that care pathways should describe steps that are considered at each stage of care. Whereas most current spine-related guidelines tend to address specific subgroups of patients such as non-specific back or neck pain or pathologies such as stenosis or radiculopathy, a comprehensive care pathway has the capacity to integrate guidelines for multiple spinal disorders into a single clinical decision tree and is, therefore, more applicable in clinical settings with limited professional resources.

There is an increased interest in developing and evaluating care pathways for musculoskeletal conditions including low back pain [2122]. However, we are not aware of a care pathway to guide the management of the full spectrum of potential presentations of spinal symptoms, concerns or pathology. This variety includes the most benign questions requiring a public health message through the most severe systemic and life-threatening destructive spinal pathologies while focusing on the most common variations of spinal pain irrespective of location (i.e., neck, middle back, low back, arm, or leg symptoms). However, other care pathways may focus on a particular symptom, such as back pain, or a specific disorder or disease, resulting in a more narrow approach to a patient care pathway. The purpose of this study was to develop a care pathway supported by current evidence-based guidelines that could apply to any person presenting with a spine-related concern, especially those who live in low- and middle-income communities or in underserved communities in high-income countries. At the same time, it was felt to be essential to prevent the use of practices that are ineffective, harmful or wasteful of limited resources and to satisfy reported concerns that fragmented and outdated models of care fail to address widespread misconceptions in the population and among health professionals about the causes, prognosis, and effectiveness of different treatments for spinal pain [6].


Criteria for care pathway development

The Global Spine Care Initiative (GSCI) steering committee, primary authors for the GSCI component articles and guest participants held several meetings to determine the essential characteristics that were required while building the pathway [23]. Criteria used to build the spinal disorders care pathway were selected from the current literature, WHO principles, and from a consensus of panelist expertise. (see Online Resource Figure 1 for guiding principles for the GSCI Pathway). This project was approved by National University of Health Sciences Institutional Review Board (#H-1503). All authors were informed about the nature of the study and the modified Delphi process and gave written consent by completing an electronic questionnaire.

The following 4 steps were completed to create a care pathway:

  • Step 1 Determine the broad categories of interventions for spinal disorders

During five face-to-face meetings, the GSCI members used a consensus process to identify six major intervention categories recommended by current guidelines for the management of different categories of spinal disorders: (1) assessment; (2) non-invasive treatment; (3) invasive treatment; (4) psychological and social; (5) prevention and public health; and (6) specialty care and interdisciplinary/multidisciplinary management [242526272829]. A review of the literature on compression fractures was included as a case study for spinal symptoms related to systemic pathology, in part because many patients with compression fractures can be managed in a primary spine care setting. The literature on the management of other serious or systemic disease with spine-related symptoms (including the inflammatory spondyloarthropathies, infections and neoplastic disorders) was not reviewed due to lack of resources. The description of interventions for these disorders was defined by referral to a specific medical specialist or tertiary spine center.

  • Step 2 Grouping of interventions into subcategories for the care pathway

Interventions recommended in the reviewed evidence-based guidelines were used to develop the care pathway. An extraction table was created to include the interventions from the GSCI foundational papers. These were consolidated into subcategories that: (1) had similar broad definitions (e.g., reassurance, imaging, non-opioid analgesics, exercise, decompression surgery); (2) could easily be differentiated based on skills or resources (e.g., manual therapy, complex fusion, cognitive behavioral therapy); (3) and had similar evidence of effectiveness and harms (e.g., exercise, non-opioid analgesics, opioids). The extraction table was reviewed by the primary authors for each of the six review articles, the principal investigators, GSCI scientific secretariat, and other GSCI co-authors to ensure that the reported content was compatible with the evidence and met reasonable health care principles. Where there was disagreement between authors, the final decision to include an intervention was determined by the primary authors of the six articles in which the evidence had been reviewed.

  • Step 3 Link interventions to the GSCI Spinal Disorders Classification system

Content from the intervention categories was linked with the different presentations as defined by the GSCI Classification system [30]. The resulting tables were reviewed by the GSCI executive team and intervention paper authors for agreement. Once an agreement was achieved, the tables were circulated among other members of the GSCI for comment and discussion.

  • Step 4 Develop a care pathway for people or patients with symptoms or concerns about spinal disorders

The primary authors of the care pathway (SH, CJ) developed a seed draft of a care pathway utilizing the tables developed in Step 3. The care pathway was based on the principles outlined (see Online Resource Figure 1). Three rounds of review and revision of the care pathway and the article were developed after receiving input from other members of the GSCI executive team and intervention chapter authors. Finally, input was requested from 70 spine care clinicians and researchers that included co-authors of the GSCI articles and individuals selected to ensure that there was both interprofessional and international representation. Responses were obtained from 53, six had no comments and felt that they had not contributed to process, four appeared to have concerns which precluded them serving as co-authors. Therefore, 46 participants from 16 countries (Australia, Botswana, Cameroon, Canada, Chile, France, Ghana, India, Iran, Kenya, Malaysia, South Africa, Spain, Switzerland, Turkey, and USA) provided input and agreed to serve as co-authors of the Care Pathway.


Figure 1 lists the major assessment; non-invasive treatment; invasive treatment; psychological and social; prevention and public health; specialty care and interprofessional management interventions that were extracted from the reviews of the literature and divided into the six broad intervention categories described in the methodology [2425262728293132]. Under each broad category of intervention, the individual interventions were divided into subsections where the mechanisms of action, outcomes, costs, and skills necessary to provide the service are similar. Interventions from the GSCI review articles are included in this table.

Fig. 1

Categories of evidence-based interventions for spine-related concerns [2526272829313233]

Care pathway

The GSCI care pathway includes five steps that are common to most clinical decision trees [22]. The GSCI care pathway guides the person who has spine-related symptoms or concerns and the clinician who is consulted through five steps and four decisions that make up the care pathway in Fig. 2. The following is a description of each step.

Fig. 2

The Global Spine Care Initiative care pathway. A person may have symptoms or concerns in one or more of the following locations: cervical, thoracic, lumbosacral, and/or entire spine. Each region should be considered separately.

Reprinted with permission from World Spine Care

  • Step 1 Awareness

The first step is when an individual with a spine-related symptom or concern becomes aware (i.e., the person has a worry that something is or will be wrong with the spine) and seeks information. The person may request information from friends, family, or health care personnel, or perform a search of the media (e.g., internet, magazines, or professional health care information sources). At this stage of the care pathway, educational materials and public health messages about spine-related concerns should include evidence-based information about risks and prognostic factors, prevention, self-assessment, and self-management. Educational messages and programs should provide adequate information so that the person is informed about when to consider self-care and when to seek care from health care personnel.

  • Step 2 Initial Triage

After considering information in Step 1, the individual decides whether or not to seek care. Initial triage may be done by those who have adequate education to read and understand the triage questions, thus may include the individual him/herself, friends, family members, health care workers, or health care providers. Information in the care pathway screening questions help to determine which major class of spinal disorder fits the spine-related concern. This information should differentiate between people with non-specific spinal pain and those who are likely to have more serious pathology requiring more advanced care.

  • Class 0. Triage Screening Questions: (1) Are there any risk factors? (2) Are there any symptoms? (3) If there are symptoms, do they interfere with function or activities? If there are minimal or no spine-related symptoms and the person is looking for information on prevention, prognosis or self-care, he or she may look for information or seek advice from a general health care setting. Examination, further assessment, or interventions beyond advice, education, and prevention recommendations are unlikely to be indicated. The majority of concerns in Class 0 would benefit from information consistent with current guidelines and do not need active care.

  • Class I. Triage Screening Questions: (1) Is pain acute/subacute (less than 3 months) or recurrent or chronic (> 3 months)? (2) Does pain interfere with function or activities? (3) Are there any neurological deficits? (4) Are there any signs of serious or systemic pathology (red flags)? Class 1 includes non-specific pain in one or more spinal regions that is not interfering with activities and has no neurological symptoms or red flags. Most people in Class I can self-manage their symptoms. If the person is not able to self-manage, the person should seek care for further assistance at a primary care setting ideally from a provider with knowledge and skills in primary spine care.

  • Class II. Triage Screening Questions: (1) Is pain acute/subacute (less than 3 months) or recurrent or chronic (> 3 months)? (2) Does pain interfere with function or activities? (3) Are there any neurological deficits? (4) Are there any signs of serious or systemic pathology (red flags)? Class II has non-specific pain in one or more spinal regions that is interfering with function or activities but without neurological symptoms or red flags. The person in this class should seek care in a primary care setting. If more advanced care is needed, the health care provider will refer to the appropriate specialty provider.

  • Class III. Triage Screening Questions: (1) Are neurological symptoms acute (recent) or chronic (longstanding)? (2) Have the neurological symptoms been getting worse? (3) Are there any signs of serious or systemic pathology (red flags)? Class III is when the person has symptoms or signs consistent with neurological compromise (numbness, weakness, loss of balance, gait disturbance or any other symptom or sign that is consistent with a neurological lesion). The person in this class should seek care in a primary care setting as soon as possible especially if the symptoms are progressive or pathologic. If more advanced care is needed, the health care provider will refer to secondary or tertiary care.

  • Class IV. Triage Screening Questions: (1) Is the deformity stable? (2) Is the deformity acute (recent) or chronic (longstanding)? (3) Are there any symptoms related to the deformity? (4) Are there any signs of serious or systemic pathology (red flags)? Class IV has serious bony structural deformity (e.g., severe scoliosis or congenital bone changes), fracture, dislocation, or instability. The person in this class should seek care in a primary care setting. If symptoms relate to pathology such as acute trauma with the possibility of fracture, severe and progressive scoliosis or instability, the person may require secondary or tertiary care on either emergency or elective basis.

  • Class V. Triage Screening Questions: (1) Is the condition acute? (2) Is it progressive? (3) Are there any signs of serious or systemic pathology (red flags)? Class V has red flags and spinal symptoms may be associated with potentially serious or systemic pathology. Depending upon the situation, the person may be referred to primary care or may be referred directly to a secondary or tertiary care setting on either emergency or elective basis.

  • Step 3 Provider assessment

If the individual triage determines that self-management is insufficient, a health care provider with knowledge and skills in spine care should be sought based upon the answers to the triage questions (e.g., for class I concerns, primary care is appropriate, for Class V the condition may require emergency care.) Spine assessment should include: (1) a detailed clinical history (e.g., onset, chronicity, severity and impact of the symptoms on function or activities of daily living); (2) the use of assessment tools to measure pain severity, disability, impairment, or other relevant outcomes: (3) identify the presence of psychological and social flags; (4) identify the presence of red flags (serious pathology); (5) relevant spinal, neurological and general physical examination; and (6) appropriate diagnostic imaging or laboratory testing [252728293132]. The history, clinical examination, and other assessments provide the information for additional triage and to assign the spine-related concern to a specific class and subclass.

  • Step 4 Intervention

Interventions are based upon the previous steps in addition to the assessment findings, available resources, and patient preferences. The clinician engages in a conversation to discuss the benefits, harms, costs, treatment alternatives, availability of the interventions within the clinical setting or community and addresses any concerns or questions the patient may have. Clinicians and patients should consider recent recommendations from the American College of Physicians that recommends non-pharmacological treatments be implemented first [34]. A shared decision is made regarding the most appropriate treatment plan and is agreed upon by the patient/family and the clinician/interdisciplinary team as recommended under WHO principles [353637] and care pathway principles [17]. The intervention is then initiated with emphasis that the patient must play an active role in his/her own health decisions.

  • Step 5 Outcomes

After the recommended interventions have been administered, completed, or discontinued, the clinician conducts a reassessment to determine the outcome of the intervention. Each patient presentation is unique and may range from benign to life-threatening. Therefore, the frequency and timing of assessments are based on the patient’s condition and response to care. Assessments should be decided on using a joint-decision-making process between the patient and health care provider. The follow-up may or may not include additional relevant assessment (e.g., history, examination, or additional testing). In most cases, there are three possible outcomes:

  1. 1.

    If the person has responded favorably, their questions have been answered, and they no longer have a need for further information or other interventions, the person is discharged.

  2. 2.

    If the person has responded somewhat favorably but requests further treatment or information, then a further assessment may be needed to determine whether he or she now falls into the same or less severe class of the GSCI classification system. If another class is assigned, the clinician will follow the steps as outlined above for that class.

  3. 3.

    If the person has not responded favorably in a reasonable timeframe or has noted increased symptoms or disability, then further assessment may be needed to determine whether he or she now falls into the same or more severe class. If in the same class, it is reasonable to consider different interventions for the same class and subclass from the table of recommended evidence-based interventions. If the patient has increased symptoms he or she may fall within a different spinal disorders class and require a different set of intervention options or referral to a higher level of spine care. If the patient has tried all available evidence-based interventions for the class and subclass that best describes his or her presentation, then consideration should be given to reassessment of the patient needs to identify other possible underlying reasons for poor response to care that may be outside of the purview of the health care system. Possible additional follow-up actions could include discharging the patient for home-care or referring to a tertiary spine care setting for multidisciplinary care, if these have not been attempted previously.


Several caveats must be considered when implementing the care pathway.

  1. 1.

    Interventions are dependent upon presentation, clinical signs and symptoms, assessment of the evidence, patient preferences, affordability of the interventions, availability and clinician knowledge/skill. Therefore, each individual presentation of a person with a spine-related concern and the clinical and cultural setting of the presentation should be considered unique. Recommendations should be consistent with the patient presentation and available resources.

  2. 2.

    The evidence and indications for specific interventions are determined from the six GSCI intervention articles and subsequently published evidence-based guidelines. Evidence, however, is not static and, as evidence evolves, the care pathway recommendations should evolve with new knowledge.

  3. 3.

    The evidence for a particular intervention may be stronger for one region of the spine than for other regions. For example, the evidence for interventions of any kind for thoracic pain is very limited. Therefore, the development of treatment options may need extrapolation of the evidence from one spinal region to other spinal regions. This should be consistent with evidence which would suggest that the extrapolation is or is not appropriate.

  4. 4.

    In the absence of red flags that may indicate the presence of a progressive disability or life-threatening diseases, interventions for each class should be viewed as treatment options. This is especially true when benefits, harms, available resources, and costs are similar. Selection of specific interventions should be determined by available resources, clinical knowledge, GSCI class of spinal disorder, the training and skill of the clinician providing care and patient preference.

  5. 5.

    Education of the public and individuals should include information on benefits, risk, and costs of all interventions irrespective of the class of spinal disorders.

  6. 6.

    A person may have more than one spinal disorder and therefore may be classified in more than one class (e.g., one class for neck pain and a different class for low back pain). From the provider point of view, the selection of interventions should match the evidence-based recommendations for the class of spinal disorders which may be different for different regions of the spine.

  7. 7.

    Management should be prioritized to the area of the spine that is the greatest of the individual’s concern or which requires the most immediate intervention to prevent progression of the condition or further harm to the patient.

  8. 8.

    With some exceptions, spinal disorders are dynamic health conditions. Therefore, their classification and management are also dynamic. An individual can move within and between classes as the condition evolves. Therefore, clinicians should monitor patients and if needed, adjust the classification during the evolution of each patient’s symptoms, impairment, or disability. The selected interventions should be consistent with the most current classification of spinal disorders and not necessarily with the initial classification.

  9. 9.

    In the majority of cases of non-specific spinal pain, management can be accomplished by a clinician with the skills and knowledge found within a primary spine care setting and it may not be necessary to consider referral to multiple clinicians or to secondary or tertiary spine care settings [38]. However, if multiple clinicians are involved in the care, at all stages of the care pathway, there should be communication among the team members and with the individual seeking care and his or her family.

  10. 10.

    In the case where there are multiple clinicians involved in care, there must be close coordination of the roles, a common goal for the interventions and sequencing of activities of each member of the multidisciplinary care team to avoid duplication, conflicting or unnecessary delays in services.

  11. 11.

    Spine care should not be considered a vertical or standalone service as this would risk disruption or fragmentation of already under-resourced health systems, especially in low- and middle-income countries. As noted by Green et al [29] and Cedrashi et al [27], spinal symptoms are commonly associated with a wide variety of co-morbid diseases and psychological and social factors that often have to be managed at the same time as the spinal symptoms. The current thinking is that initiatives should be integrated into health systems in low- and middle-income countries [39].


This is the first attempt by an interprofessional and international task force to create a care pathway that may accommodate all individuals presenting with spine-related symptoms, concerns, or risk factors. The proposed care pathway is based on evidence-based practices and patient’s expectations and allows the clinician a level of flexibility based on available resources [1718]. We hope that this pathway provides a consistent approach to the provision of health care services while at the same time considering available health care resources in underserved communities.

The GSCI Care Pathway is consistent with a proposed approach to low back pain [40]. This approach uses current evidence to guide practice and focuses on the importance of public health policy, self-care and education of the general population, patients and clinicians concerning prevention strategies and expectation from interventions [56]. It is insufficient to focus only on low back pain. Instead, we must also include neck concerns and other spine-related symptoms and the higher incidence of untreated serious spinal pathology that may present in underserved communities.

We recommend a care pathway with five sequential steps irrespective of the clinical setting. Our hope is that its simplicity may facilitate communication between clinicians, patients, and their communities. The pathway aims to reduce confusion by clarifying the most appropriate manner in which a person with spinal symptoms should be managed. Improved communication allows for interventions that emphasize appropriate self-care and avoids reliance on unnecessary treatments. Our assumption is that common understanding and application of an evidence-based approach to spinal disorders will lead to improved outcomes and less costly care.

The care pathway, however, requires that clinicians who manage people with spine-related symptoms have the knowledge, skills, and resources to apply evidence-based care. The pathway provides a guide to what care should be considered in primary, secondary and tertiary spine care settings [41]. The pathway does not require high cost, high technology interventions for the majority of people who present with spinal concerns. In this way, the care pathway may be implemented in most clinical settings, but especially in communities with limited resources such as in low- and middle-income countries. For primary, secondary and tertiary settings that do not have providers with the knowledge, skills, and resources to apply evidence-based spine care, it may be necessary to establish a training program.

The care pathway may be used by clinicians from different clinical disciplines and different specialties or if a clinician has limited training in managing of spinal disorders. The care pathway was developed so it could be displayed in a chart or easily adapted into an electronic medical record or educational tool. A clinician should be able to review the pathway and quickly determine the class or subclass, the assessments, and the relevant evidence-based interventions. The clinician can then select which recommended interventions are available in the current clinical setting and then review the options with the patient and/or family members to describe the benefits, harms, and costs of the different intervention options and incorporate the patient’s preferences. This approach is consistent with the WHO principles of interprofessional “collaborative practice-ready” health care [36]. The care pathway also follows the WHO principles of incorporating integrated, people-centered health services, which is considered an essential element of continuity of care, defragmenting of health systems and improving health care outcomes by the WHO [353637].

This care pathway was developed to be implemented in communities with varying resource capacities, available health care providers, and public health personnel. The triage process helps to differentiate people who may not require professional spine care from those who can be managed with available resources in a health care setting, and those who require referral to a health care setting with higher levels of resources. Low-income communities may consider prioritizing interventions within the options recommended for each class to conform to the available resources including the relative costs of, and availability of the treatment options.

Strengths and limitations

The GSCI care pathway was developed by an international, interprofessional team of clinicians, scientists, and stakeholders from high-, middle- and low-income countries and based on a model recommended by the WHO which includes person-centered health services [353637]. The pathway considers available resources, clinician skills, and patient preferences and focusses on evidence-based interventions. It is consistent with, and incorporates currently used guidelines and has the capacity to evolve as new guidelines are published. The pathway was developed to accommodate all people who may present with spine-related symptoms or concerns, is not limited to a specific symptom (i.e., pain) or spinal region (low back or neck) or chronicity and does not require a pathological diagnosis for axial spinal pain. This pathway incorporates psychological and social factors, takes into consideration public health interventions and addresses people who present with neurological symptoms, structural pathology, serious and life-threatening systemic pathology. These features should facilitate the implementation of this pathway in a wide variety of health care settings.

Limitations include that not all of the 68 GSCI experts participated in the development of the care pathway and therefore is subject to bias. Like any care pathway, its value will depend on field testing to determine whether it can be implemented in communities with different cultures and resources. The care pathway described here has not yet been tested for validity and reliability. It is also necessary to determine whether it can be easily administered and utilized by all stakeholders including patients and clinicians. Resources and the implementation of the model of care are described elsewhere [3841]. The final determination of the value of this care pathway will be its acceptance by patients and clinicians with different expectations or training, the ability to implement the care pathway and the determination as to whether, when implemented, it has the desired outcomes of reduced costs and disability associated with spinal disorders.


This is the first international and interprofessional attempt to develop a care pathway for the management of any person presenting with spine-related symptoms or concerns that incorporate the recommendations from multiple evidence-based guidelines. The decision steps are person-centered, community-based and consistent with recommendations established by the WHO, evidence-based and limited to five steps. This care pathway will need to be field tested in different cultural and resource communities to determine its utility.



The Global Spine Care Initiative and this study were funded by grants from the Skoll Foundation and NCMIC Foundation. World Spine Care provided financial management for this project. The funders had no role in study design, analysis, or preparation of this paper.

Compliance with ethical standards

Conflict of interest

SH declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. Clinical Policy Advisory Board and stock holder, Palladian Health. Advisory Board, Book Royalties, McGraw Hill. Travel expense reimbursement—CMCC Board. CDJ is president of Brighthall Inc; she is an NCMIC Board of Director; however, neither she nor NCMIC board makes funding decisions for the NCMIC Foundation; the views in this article are those of the authors and not those of Stanford University, Stanford Health Care, or Qualcomm. RC declares funding from AHRQ to conduct systematic reviews on treatments for low back pain within last 2 years. Honoraria for speaking at numerous meetings of professional societies and non-profit groups on topics related to low back pain (no industry sponsored talks). MN declares funding from Skoll Foundation and NCMIC Foundation through World Spine Care;. Co-Chair, World Spine Care Research Committee. Palladian Health, Clinical Policy Advisory Board member. Book Royalties Wolters Kluwer and Springer. Honoraria for speaking at research method courses. PC is funded by a Canada Research Chair in Disability Prevention and Rehabilitation at the University of Ontario Institute of Technology, and declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. Canadian Institutes of Health Research Canada. Research Chair Ontario Ministry of Finance. Financial Services Commission of Ontario. Ontario Trillium Foundation, ELIB Mitac. Fond de Recherche and Sante du Quebec. EH declares he is a consultant for: RAND Corporation; EBSCO Information Services; Southern California University of Health Sciences; Western University of Health Sciences Data and Safety Monitoring Committee. Chair, Palmer Center for Chiropractic Research. Research Committee Co-chair, World Spine Care. BNG receives speaker fees and travel reimbursement from NCMIC Speakers’ Bureau; he is secretary of Brighthall Inc; the views in this article are those of the authors and not those of Stanford University, Stanford Health Care, or Qualcomm. EAc declares grants: Depuy Synthes Spine, Medtronic; Speaker’s Bureau: AOSpine, Zimmer Biomet. DKG declares travel expenses: CMCC to present at the WSC Spine Conference in Botswana. OB declares he is a consultant for: Pacira Pharmaceuticals, Inc. Palladian Health. Travel expenses: World Spine Care. Stipend: World Spine Care. PB declares contribution to salary for Global Musculoskeletal Alliance (G-MUSC), The Bone and Joint Decade work. JMC declares Government Grant ESPY 1281/15. CG declares travel expenses: Palmer College to GSCI meetings. Consultant: American Chiropractic Association, Spine IQ, Healthwise, Quality Insights of Pennsylvania, RAND Co.; Prezacor, Inc. (Stock Options). PCORI (Board Member). Grants: Collaborative Care for Veterans with Spine pain and Mental Health Issues. NIH/ Kiernan Chiropractic Care in Rehabilitation at Crotched Mountain: Crotched Mountain Private Sector Integrated Chiropractic Study N/A. NCMIC Foundation Chiropractic services, Assessment of Chiropractic Treatment for Low Back Pain; RAND Subcontract, Department of Defense Prime Award #W81XWH-11-2-017 Sub #9920110071. MH declares travel support from World Spine Care. JM declares general research resources from USF Research Center. Research grants from funding agencies: FEMA, US Department of Homeland Security (EMW-2013-FP-00723). Palladian Health Advisory board: Clinical Policy and Advisory Board,. Intellectual property rights: Inventor of Web-based system to deliver exercise (Employer - USF: copyright holder). TM declares Fellowship grant-Medtronics. JM declares WSC Board Member. EM declares AO Spine Africa Faculty courses - honorarium. GO declares he is a consultant and receives travel support as Clinic Director, World Spine Care. KR declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. HR declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. ES declares funding from Başkent University Research Fund. LV declares funding to UOIT from Skoll Foundation and NCMIC Foundation through World Spine Care. WW declares Palladian Health, Clinical Policy Advisory Board member. HY declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care, the remaining authors declare that they have no conflict of interest.

Supplementary material

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Supplementary material 1 (PDF 91 kb)
586_2018_5721_MOESM2_ESM.pptx (658 kb)

Supplementary material 2 (PPTX 657 kb)


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