R.J. Westerhuisa, R.L. van Bezooijenb, c and P. Kloena.
aDepartment of Orthopaedic Surgery, Academic Medical Center, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands bDepartment of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands cDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
An estimated 510% of all fractures show impaired healing, leading to delayed union, or non-union. Chemical, or physical methods to accelerate bone healing are of great interest to the orthopaedic and trauma community. Research over the last 20 years has established that successful fracture healing is steered by specific growth factors. Of these, the bone morphogenetic proteins (BMPs) are probably the most important. The signalling pathway of these proteins is tightly regulated, overseeing a finely orchestrated cascade of events that occur after a fracture. The promising results of BMPs in preclinical studies have recently cleared the way for their use in specific fractures, or non-unions in clinical practice. The purpose of this work is to give a brief overview of BMPs and to review the clinical data currently available on the use of BMPs in fracture healing.
Injury Volume 36, Issue 12 , December 2005, Pages 1405-1412.