Claus, Alexandra M MD, PHD *; Totterman, Saara M MD, PHD +; Sychterz, Christi J MS ++; Tamez-Pena, Jose G PHD [S]; Looney, R John MD [forms double vertical]; Engh, Charles A Sr MD [P]
To assess the accuracy of a computer-assisted computed tomography image analysis program in determining the location and volume of periacetabular osteolysis, we designed an osteolysis model by implanting bilateral total hip replacements in human pelvic cadavers and creating osteolytic lesions of varying sizes. The volumes of 48 defects were measured physically, and axial computed tomography scans were obtained. The computed tomography images were processed with streak artifact reduction and segmentation algorithms. The location and volume of lesions were determined from these images. Eighty-one percent (39 lesions) were identified correctly from the computed tomography scans. Detection was location-dependent. More lesions were detected in the ilium (100%) and at the rim (89%) than in the ischium (78%) or the pubis (50%). Computed tomography overestimated lesion volume by a mean of 0.5 +/- 2.3 cm3. The volumetric error was unrelated to lesion location but was dependent on lesion size. As lesion size increased above 10 cm3, the mean percentage error decreased to 1.8%. Computed tomography image analysis can be used more accurately than plain radiographs to investigate the effectiveness of treatment and the natural history of pelvic osteolysis.
Clinical Orthopaedics & Related Research. 1(422):167-174, May 2004.