Heather A Jackson, PharmD1, and Amy Heck Sheehan, PharmD2
1 Drug Information Specialty Resident, Purdue University/Clarian Health Partners, Indianapolis, IN 2 Associate Professor of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University; Drug Information Specialist, Clarian Health Partners
Reprints: Dr. Jackson, Clarian Health Partners Pharmacy Department, Rm. AG 401, I-65 @ 21st St., Indianapolis, IN 46202-1367, fax 317/962-1756, firstname.lastname@example.org
OBJECTIVE: To describe current data evaluating the effect of vitamin A intake on fracture risk.
DATA SOURCES: A literature search using MEDLINE (1966-March 2005) was conducted using the search terms bone density, fractures, osteoporosis, retinol, and vitamin A to identify published studies evaluating the effects of vitamin A on bone.
DATA SYNTHESIS: Studies evaluating vitamin A consumption and fracture risk were reviewed. Current data suggest a potential inverse relationship between excess vitamin A consumption and bone mineral density leading to an increased risk for fracture.
CONCLUSIONS: Although current data are limited, consumption of large amounts of vitamin A may be associated with decreased bone mineral density and increased fracture risk. Until further information is available, patients should be made aware of the potential risks of consuming vitamin A in amounts that exceed the recommended dietary allowance. Further research is needed to clarify the relationship between vitamin A and fracture risk.
The Annals of Pharmacotherapy: Vol. 39, No. 12, pp. 2086-2090. DOI 10.1345/aph.1G028.