«Cambios longitudinales en la salud del hueso valorado por velocidad del sonido en niños de muy bajo peso al nacimiento.»
C. Tomlinson MBChB, MRCPCH⁎, H. McDevitt MBChB, MRCPCH⁎, S.F. Ahmed MD, FRCPCH and M.P. White MBChB, FRCP, FRCPCH,
From the Neonatal Unit, Princess Royal Maternity Hospital, Glasgow; the Paediatric Department, Queen Mothers Hospital, Yorkhill, Glasgow; the Neonatal Unit, Southern General Hospital, Glasgow; and the Bone & Endocrine Research Group, Royal Hospital For Sick Children, Yorkhill, Glasgow.
Objective To assess longitudinal changes in speed of sound (SOS) in very low birth weight (VLBW) infants and investigate the relationship with markers of osteopathy of prematurity (OP) and clinical illness.
Study design Twenty-five infants were recruited. Eighteen infants, median gestation 27 weeks (range 2432), median birth weight 957 g (range 6251500 g), had serial scans. SOS was measured at both tibiae weekly until 35 to 37 weeks corrected gestational age (CGA).
Results Initial median SOS standard deviation score (SDS) (Z) score was −0.07 (range −1.31.3). SOS correlated with gestation (r, 0.8, P <.005), and birth weight (r, 0.67, P <.005.) SOS fell from a median of 2923 m/s (26723107) at birth to 2802 m/s (25022991) at 35 to 37 weeks CGA (P <.05). This fall was greater in the 24- to 27-week gestation cohort with a median reduction of 2.2 SDS (1.6, 4.0) compared with 1.3 SDS (0.82.2) in those >28 weeks (P <.05). There was a negative correlation between SOS, at the end of the study, peak serum alkaline phosphatase (ALP) (r, 0.6, P <.05), CRIB (Clinical Risk Index for Babies)/CRIB II scores (both r, 0.6, P <.05), and duration of total parenteral nutrition (TPN) (r, 0.58, P <.05.)
Conclusions Although tibial SOS was within the expected range at birth, there was a subsequent failure to gain SOS, and this was most marked in infants of a lower gestation.
The Journal of Pediatrics Volume 148, Issue 4 , April 2006, Pages 450-455.