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Metabolismo Óseo y Mineral

Recent developments in the management of postmenopausal osteoporosis with bisphosphonates: enhanced efficacy by enhanced compliance

Última actualización 13/10/08J Intern Med. 2008 Oct;264(4):315-32. Boonen S, Vanderschueren D, Venken K, Milisen K, Delforge M, Haentjens P. Bisphosphonates are the current mainstay of treatment for postmenopausal osteoporosis. Although daily oral dosing is effective, it is associated with poor compliance, partly because of the pre and postdose fasting and …

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Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling

Última actualización 8/07/08NULL Bone. 2008 Jun 3. [Epub ahead of print] McDonald MM, Dulai S, Godfrey C, Amanat N, Sztynda T, Little DG. Orthopaedic Research and Biotechnology, The Children’s Hospital at Westmead, Westmead Australia; Science Department, University of Technology Sydney, Australia. INTRODUCTION: It has been widely assumed that osteoclasts play …

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Significance of a decline in bone mineral density while receiving oral bisphosphonate treatment

Última actualización 2/05/08NULL Sebba AI. Clin Ther. 2008 Mar;30(3):443-52. Background: Oral bisphosphonates are routinely prescribed for the treatment of postmenopausal osteoporosis. In clinical trials, oral bisphosphonates have been found to increase bone mineral density (BMD) and decrease fracture risk in the majority of the treated population. However, in both clinical …

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An emerging pattern of subtrochanteric stress fractures: A long-term complication of alendronate therapy?

Última actualización 17/03/08NULL Injury. 2008 Feb;39(2):224-31. Epub 2008 Jan 28. Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. BACKGROUND: Subtrochanteric insufficiency fractures in post-menopausal patients have not been commonly reported in the literature. A recent increase in the incidence of such fractures occurring in patients while on alendronate …

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